OpenEvidence Raised $250 Million at $15 Billion Value

AI search platforms are gaining traction as healthcare systems integrate tools into clinical workflows.

Updated on Sept. 28, 2026 in Healthcare

Isometric editorial illustration of a stack of glass plates with etched geometric patterns, representing integrated healthcare data systems. — OpenEvidence secured $250 million in its latest funding round, bringing the healthcare AI platform's valuation to $15 billion as it integrates with major health systems. AI Illustration. Upload story photo >

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OpenEvidence secured $250 million in its latest funding round, pushing the healthcare AI platform to a $15 billion valuation. The company has raised nearly $1 billion since its 2022 founding.

Why it matters

The company's rapid valuation growth reflects the intensifying demand for AI-driven clinical tools that integrate directly into provider workflows. As these platforms reach majority adoption among physicians, their role in guiding treatment decisions continues to expand.

The company reached a $15 billion valuation, up from $12 billion in January 2026, fueled by a new $250 million funding round. With more than 50% of U.S. physicians now using the platform, total capital raised has reached nearly $1 billion.

The players

OpenEvidence

An AI platform that provides clinical search results integrated into hospital electronic health record systems.

Andreessen Horowitz

A venture capital firm that invests in technology companies and led the latest OpenEvidence funding round.

Byers Capital

A venture capital investment firm that co-led the recent funding round for OpenEvidence.

Mount Sinai Health System

A major New York City-based integrated healthcare network that incorporates OpenEvidence into its clinical workflows.

Sutter Health

A large California-based not-for-profit health system that integrates the OpenEvidence platform into its Epic software.

The details

OpenEvidence provides an AI-powered search tool that delivers answers derived from peer-reviewed clinical studies and established guidelines. These insights are embedded directly into Epic health system workflows, allowing physicians to access evidence-based data during patient care. Mount Sinai Health System and Sutter Health are currently among the institutions utilizing this integration.

OpenEvidence was founded in 2022.
The previous series D funding round occurred in January 2026.
The new funding round was confirmed in September 2026.

Market Landscape

The funding round highlights the growing reliance on specialized AI search tools within established electronic health record systems like Epic. This trend marks a move toward embedding external evidence-based analytics directly into the daily clinical decision support workflow.

Operators should monitor whether AI-search integration leads to measurable shifts in clinical speed or diagnostic outcomes at their own facilities. Consider auditing current EHR vendor partnerships to identify opportunities for similar AI-driven workflow enhancements.

The takeaway

The successful capital raise suggests strong institutional confidence in the scalability of AI tools embedded in clinical environments. Leaders should evaluate how the integration of evidence-based search tools affects both provider efficiency and potential malpractice liability profiles.